4-amino (aza) quinoline derivatives as capsaicin receptor...

Details 4-amino (aza) quinoline derivatives as capsaicin receptor... 4-amino (aza) quinoline derivatives as capsaicin receptor...

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/4375 (2006.01) A61K 31/4706 (2006.01) A61K 31/4985 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) C07D 213/56 (2006.01) C07D 215/44 (2006.01) C07D 235/14 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 475/04 (2006.01)

Patent

CA 2540342

Capsaicin receptor agonists are provided. Such compounds are ligands that may be used to modulate VRl activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to capsaicin receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

La présente invention concerne des agonistes des récepteurs de la capsicine. Ces composés sont des ligands convenant à la modulation de l'activité VRI in vivo comme in vitro. Ils conviennent donc particulièrement au traitement d'états réagissant à l'activation des récepteurs de la capsicine, chez l'humain, les animaux de compagnie, et les animaux d'élevage. La présente invention, qui concerne notamment des compositions pharmaceutiques et des procédés les utilisant pour traiter de tels troubles, concerne également des procédés permettant d'utiliser de tels ligands pour l'étude de localisation de ces récepteurs.

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