4-amino derivatives of 5-substituted mycophenolic acid

C - Chemistry – Metallurgy – 07 – D

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C07D 307/88 (2006.01) A61K 31/365 (2006.01) A61K 31/395 (2006.01) A61K 31/665 (2006.01) C07D 405/02 (2006.01) C07D 405/06 (2006.01) C07D 407/06 (2006.01) C07D 409/06 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2183531

The disclosed derivatives of mycophenolic acid of formula (IE) are therapeutic agens advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents. In said formula, Z is a side chain selected from formulae (ZA, ZB, ZC, ZD, ZE, ZF, ZG, and ZH).

L'invention porte sur des dérivés de l'acide mycophénolique de formule (IE) servant d'agents thérapeutiques traitant avantageusement les états morbides relevant de l'acide mycophénolique et/ou du mycophénolate mofétil et d'autres agents immunodépresseurs. Dans cette formule, Z est une chaîne latérale de formule (ZA, ZB, ZC, ZD, ZE, ZF, ZG ou ZH).

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