C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 487/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2243994
The present invention relates to 4-amino pyrimidine derivatives of general formula (I), where Ra, Rb, A and B are as defined in claim 1, their tautomers, stereoisomers and salts, especially their physiologically acceptable salts with inorganic or organic acids or bases, having valuable pharmacological properties, especially an inhibitory effect on signal transduction produced by tyrosinkinases, their use in the treatment of disorders, especially tumours, and their production.
La présente invention concerne des dérivés de 4-amino-pyrimidine de formule générale (I), dans laquelle R¿a?, R¿b?, A et B sont définis dans la revendication 1, leurs tautomères, leurs stéréo-isomères et leurs sels, notamment leurs sels physiologiquement acceptables avec des acides ou des bases inorganiques ou organiques, lesdits composés présentant des propriétés pharmacologiques intéressantes, notamment un effet inhibiteur sur la transduction de signal par les tyrosine kinases. L'invention concerne également leur utilisation pour le traitement de maladies, notamment les maladies tumorales, ainsi que la production desdits composés.
Dahmann Georg
Himmelsbach Frank
Metz Thomas
von Ruden Thomas
Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung
Fetherstonhaugh & Co.
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