C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 31/675 (2006.01) A61P 35/00 (2006.01) C07D 239/94 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07F 9/40 (2006.01)
Patent
CA 2361174
The present invention relates to bi-cyclic heterocycles of general formula (I), wherein R a to R d, A to G and X are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof particularly the physiologi-cally acceptable salts thereof with inor-ganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.
La présente invention concerne des hétérocycles bicycliques représentés par la formule générale (I) dans laquelle Ra à Rd, A à G, et X sont tels que définis dans la revendication 1, ainsi que leurs tautomères, stéréo-isomères et sels, notamment leurs sels physiologiquement acceptables avec des acides ou des bases inorganiques ou organiques. Ces composés possèdent des propriétés pharmacologiques intéressantes, notamment un effet inhibiteur sur la transduction de signal par les tyrosine kinases. L'invention concerne également leur utilisation pour le traitement de maladies, en particulier les maladies tumorales, les affections des poumons et des voies respiratoires, et leur préparation.
Blech Stefan
Himmelsbach Frank
Jung Birgit
Langkopf Elke
Metz Thomas
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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