4 amino quinolines and naphthyridines, process for their...

C - Chemistry – Metallurgy – 07 – D

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C07D 215/54 (2006.01) A61K 31/435 (2006.01) C07D 215/42 (2006.01) C07D 215/60 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1337073

Disclosed are 4-amino quinolines and naphthyridines of the general formula: Image I in which R1 and R2 are selected from hydrogen, C1-C6 alkyl or alkylene, phenyl or benzyl or R1 and R2 form together with the nitrogen atom to which they are attached a C4-C8 saturated heterocycle, R3 is selected from hydrogen, C1-C6 alkyl, phenyl or C7-C9 phenyl-alkyl, R4 is selected from hydrogen or C1-C4 alkyl, R5 and R6 are selected from hydrogen or halogen, C1-C3 alkyl or alkoxy, nitro or trifluoromethyl; Z is selected from OH, C1-C6 alkoxy, C1-C4 alkyl, benzyl, C4-C6 aryl with or without a heteroatom, or NR8R9, R8 and R9 being selected from hydrogen, C1-C4 alkyl, phenyl or benzyl; R10 is selected from hydrogen, C1-C4 alkyl or phenyl; n is 0, 1 or 3, p is 0 or 1 and one of the symbols A, B, C, D represents N and the others CH or A, B, C, D all represent CH and their acid addition salts, and their salts with bases. These compounds can be used in the man medecine, for the prevention and treatment of cardiovascular diseases or also as antiallergic drugs and in the prevention and treatment of infectious states or for the treatment of anxiety. To animals,they can be used for the prevention and treatment of infections conditions.

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