4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives,...

Details 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives,... 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives,...

C - Chemistry, Metallurgy

07

D

C07D 235/26 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2278747

Disclosed are compounds of formula (I), wherein R1 is hydrogen or C1-C6 alkyl; R2 is selected from hydrogen, straight-chain and branched C1-C10 alkyl, cyclohexylmethyl or -(CH2)mAr where Ar is phenyl, naphthyl, thienyl, furanyl or pyridinyl, each optionally substituted by one or two substituents selected independently from C1-C6 alkyl, halogen, C1-C6 alkoxy and trifluoromethyl; or NR1R2 is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2- yl; m is 1-5; n is 1 or 2; R3 is hydrogen or C1-C6 alkyl; Y is halogen, C1-C6 alkyl, and C1-C6 alkoxy; or a pharmaceutically acceptable salt thereof, which are dopamine autoreceptor agonists and as such are useful in the treatment of schizophrenia, Parkinson's disease, Tourette's syndrome, alcohol addiction and drug addiction.

L'invention concerne des composés de la formule (I) ou bien un sel pharmaceutiquement acceptable de ceux-ci. Dans cette formule, R?1¿ est hydrogène ou alkyle C¿1?-C¿6?; R?2¿ est choisi parmi hydrogène, alkyle C¿1?-C¿10? à chaîne droite ou ramifié, cyclohexyméthyle ou bien -(CH¿2?)¿m?Ar où Ar est phényle, napthyle, thiényle, furanyle ou pyridinyle, éventuellement substitués par un ou deux substituants choisis indépendamment parmi alkyle C¿1?-¿6?, halogène, alcoxy C¿1?-C¿6? et trifluorométhyle; ou bien NR?1¿R?2¿ est 1,2,3,4-tétrahydroquinoléin-1-yle ou 1,2,3,4-tétrahydroisoquinoléin-2-yle; m vaut 1-5; n vaut 1 ou 2; R?3¿ est hydrogène ou alkyle C¿1?-C¿6?; Y est halogène, alkyle C¿1?-C¿6?, et alcoxy C¿1?-C¿6?. Ces composés sont des agonistes des autorécepteurs de la dopamine et à ce titre sont utiles dans le traitement de la schizophrénie, de la maladie de Parkinson, de la maladie de Gilles de La Tourette, de l'alcoolisme et de la toxicomanie.

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