4-aminoethoxy-indolone derivatives as dopamine d2 agonists

Details 4-aminoethoxy-indolone derivatives as dopamine d2 agonists 4-aminoethoxy-indolone derivatives as dopamine d2 agonists

C - Chemistry, Metallurgy

07

D

C07D 409/12 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2264072

A compound of formula (I) in which Y is hydrogen, halogen or alkoxy; R is hydrogen or alkylthio; R1 is hydrogen or alkyl; X is hydrogen, halogen, alkoxy, alkyl or phenyl; n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of shizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

Cette invention se rapporte à un composé représenté par la formule (I) dans laquelle Y est hydrogène, halogène ou alcoxy; R est hydrogène ou alkylthio; R¿1? est hydrogène ou alkyle; X est hydrogène, halogène, alcoxy, alkyle ou phényle; n est un entier égal à 1, 2, 3 ou 4. Ledit composé et ses sels pharmaceutiquement acceptables sont des inhibiteurs de synthèse et de libération de la dopamine, qui s'avèrent utiles dans le traitement de la schizophrénie, de la maladie de Parkinson, de la maladie de Gilles de La Tourette, de la toxicomanie alcoolique, de la cocaïnomanie et de la toxicomanie associée à des drogues analogues.

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