4-aminoethoxyindazole derivatives

Details 4-aminoethoxyindazole derivatives 4-aminoethoxyindazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/415 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2278746

This invention relates to dopamine D2 agonists of formula (I), wherein: Y is hydrogen, halogen, or C1-C6 alkoxy; R1 is hydrogen or C1-C6 alkyl; X is methylene, oxygen or carbonyl; Ar is phenyl or thienyl, each optionally substituted with 1-2 groups independently selected from C1-C6 alkoxy, C1-C6 alkyl, halogen, trifluoromethyl and phenyl; n=0-4, or pharmaceutically acceptable salts thereof. Dopamine D2 agonists are useful in the treatment of schizophrenia, Tourette's syndrome, drug and alcohol addiction, and also useful in the treatment of Parkinson's disease.

L'invention porte sur des agonistes de la dopamine D¿2?, de formule (I) dans laquelle: Y est H, halogène, ou C¿1?-C¿6? alkoxy; R?1¿ est H ou C¿1?-C¿6? alkyle; X est méthylène, O ou carbonyle; Ar est phényle ou triényle, chacun d'eux étant facultativement substitué par des groupes 1-2 choisis indépendamment parmi C¿1?-C¿6? alkoxy, C¿1?-C¿6? alkyle, halogène, trifluorométhyle et phényle; n est 0-4, ou sur leurs sels pharmacocompatibles. Les agonistes de la dopamine D¿2? peuvent être utilisés dans le traitement de la schizophrénie, du syndrome de Tourette, de la toxicomanie ou de l'alcoolisme, et également dans celui de la maladie de Parkinson.

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