4-aminomethyl benzamidine derivatives and their use as...

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 257/18 (2006.01) A61K 31/155 (2006.01) C07C 255/60 (2006.01) C07C 259/18 (2006.01) C07C 271/64 (2006.01) C07D 207/26 (2006.01) C07D 209/48 (2006.01) C07D 211/58 (2006.01) C07D 213/30 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/42 (2006.01) C07D 213/56 (2006.01) C07D 213/65 (2006.01) C07D 213/75 (2006.01)

Patent

CA 2577608

The invention is concerned with novel 4-aminomethyl benzamidine derivatives of formula (I) wherein Ar and X are as defined in the description and in the claims, as well as prodrugs and pharmaceutically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.

La présente invention a trait à de nouveaux dérivés de 4-aminométhyl benzamidine de formule (I), dans laquelle Ar et X sont tels que définis dans la description et dans les revendications, ainsi que leurs prodrogues et leurs sels pharmaceutiquement acceptables. Ces composés sont inhibiteurs de la formation de facteurs de coagulation Xa et IXa et de la thrombine induite par le facteur VIIa et peuvent être utilisés comme médicaments.

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