C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2629554
The present invention relates to novel 4-aminopyrimidine-5-thione 5 derivatives of the formula (I), and their pharmaceutically acceptable salts, which inhibit cyclin-dependent kinases, in particular Cdk1, Cdk2 and Cdk4, therefore have antiproliferative activity and are thus useful in the treatment or control of cancer, in particular solid tumors more particularly breast , lung, colon and prostate tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast , lung, colon and prostate tumors.
La présente invention concerne des nouveaux dérivés de 4-aminopyrimidine-5-thione 5 représentés par la formule (I), ainsi que leurs sels pharmaceutiquement acceptables, lesquels inhibent les kinases dépendantes des cyclines, en particulier Cdk1, Cdk2 et Cdk4, lesquels présentent une activité antiproliférante et sont utiles dans le traitement du cancer ou la lutte contre le cancer, en particulier des tumeurs solides et plus particulièrement, des tumeurs du sein, des poumons, du colon et de la prostate. Cette invention concerne également des compositions pharmaceutiques contenant de tels composés ainsi que des méthodes permettant de traiter un cancer ou de lutter contre un cancer et plus particulièrement de traiter ou de lutter contre un des tumeurs du sein, des poumons, du colon et de la prostate.
Ding Qingjie
Jiang Nan
Lovey Allen John
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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