4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles

Details 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2354510

4- and 5-alkynyloxindoles as well as 4- and 5-alkenyloxindoles having formula (I) and (II), wherein R1, R2, R3, R11, R12, X and z have the meaning indicated in the specification, inhibit or modulate protein kinases, in particular JNK protein kinases and are useful as anti-inflammatory agents, particularly in the treatment of rheumatoid arthritis.

L'invention concerne des 4- et 5-alkynyloxindoles ainsi que des 4- et 5-alcényloxindoles représentés par les formules (I) et (II), dans lesquelles R?1¿, R?2¿, R?3¿, R?11¿, R?12¿, X et z ont la signification indiquée dans la description. Ces composés inhibent ou modulent les protéines kinases, notamment les protéines kinases JNK, et ils sont utilisés comme agents anti-inflammatoires pour le traitement de la polyarthrite rhumatoïde notamment.

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