4-anilino-quinazoline derivatives as antiproliferative agents

Details 4-anilino-quinazoline derivatives as antiproliferative agents 4-anilino-quinazoline derivatives as antiproliferative agents

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 239/94 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2526897

A quinazoline derivative of the formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.

L'invention concerne un dérivé de quinazoline représenté par la formule (I), dans laquelle les substituants sont tels que définis dans le descriptif. Ce dérivé est destiné à être utilisé dans la production d'un effet antiprolifératif, cet effet étant produit uniquement ou partiellement par l'inhibition des tyrosines kinases erbB2 associées au récepteur chez un animal à sang chaud, notamment un humain.

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