4-anilino quinazoline derivatives as antiproliferative agents

Details 4-anilino quinazoline derivatives as antiproliferative agents 4-anilino quinazoline derivatives as antiproliferative agents

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2479642

The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, R1 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.

La présente invention concerne des dérivés de quinazoline représenté par la formule (I); dans cette formule, chacun des éléments Q?1¿, Z, R?1¿ et Q?2¿ est tel que défini dans le descriptif. L'invention concerne également des procédés de préparation de ces dérivés, des compositions pharmaceutiques les contenant, ainsi que l'utilisation de ces dérivés pour la fabrication d'un médicament utilisable en tant qu'agent antiprolifératif pour prévenir ou traiter des tumeurs qui sont sensibles à l'inhibition des tyrosine kinases du récepteur erbB.

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