C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2510323
The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3 and R5 are as defined herein, and wherein the compound of formula (1) optionally further comprises a hydroxy substituent or an 0-glucuronic acid. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).
La présente invention concerne des composés de formule (1) et des sels, promédicaments et solvates de ceux-ci, acceptables d'un point de vue pharmaceutique. Dans la formule (1), R?1¿, R?2¿, R?3¿ et R?5¿ sont tels que définis dans l'invention. Le composé de formule (1) comprend éventuellement aussi un substituant hydroxy ou un acide O-glucuronique. La présente invention concerne également des procédés pour traiter une croissance cellulaire anormale chez des mammifères, qui consistent à administrer les composés de formule (1), ainsi que des compositions pharmaceutiques pour traiter de tels troubles, qui contiennent les composés de formule (1). En outre, cette invention concerne des procédés pour préparer les composés de formule (1).
Brown Maria Steflik
Kath John Charles
Liu Zhengyu
Szewc Ruby Anthea
Truesdell Susan Jane
Pfizer Products Inc.
Smart & Biggar
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