C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/517 (2006.01)
Patent
CA 2558501
The present invention relates to the use of 4-anilinoquinazoline derivatives as adenosine-kinase inhibitors. The present invention also relates to a method for protecting tissues and organs like heart, brain and kidneys affected by ischemia, and for treating heart insufficiency, myocardium infarct, arrhythmia, arterial hypertension, atherosclerosis, coronary artery restenosis after angioplasty, chronic renal insufficiency, cerebral vascular accident, and chronic inflammatory diseases (e.g. rheumatoid arthritis). The present invention also relates to the compound 6,7--dimethoxy- 4- (3'-N',N'-dimethylaminoanilino)quinazoline, or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising it and use of such compound in the manufacture of a medicament for treating or preventing diseases or conditions which are benefited from the adenosine kinase inhibition.
L'invention concerne des composés qui sont des inhibiteurs d'adénosine-kinase. Elle concerne un procédé qui permet de protéger des tissus et des organes tels que le coeur, le cerveau et les reins affectés par l'ischémie, et de traiter l'insuffisance cardiaque, l'infarctus du myocarde, l'arythmie, l'hypertension artérielle, l'athérosclérose, la resténose de l'artère coronaire après une angioplastie, l'insuffisance rénale chronique, l'accident vasculaire cérébral et des maladies inflammatoires chroniques (par exemple la polyarthrite rhumatoïde). L'invention concerne également l'effet inhibiteur d'adénosine-kinase des composés dérivés de quinazolines, antérieurement connus comme inhibiteurs réversibles de tyrosine-kinases de la famille des récepteurs du facteur de croissance épidermique (EGFR).
Abdalla Saad Mario Jose
Gomes Franchini Kleber
Marin Rodrigo Miguel
Rittner Neto Roberto
Rocco Aparecida Silvana
G. Ronald Bell & Associates
Universidade Estadual de Campinas-Unicamp
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