4-anilinoquinoline-3-carboxamides as csf-1r kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 215/54 (2006.01) A61K 31/47 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2649146

The invention relates to chemical compounds of formula IA or IB: formula IA IB or pharmaceutically acceptable salts thereof which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti cancer effect in a warm blooded animal such as man.

L'invention porte sur des composés chimiques de formule IA ou IB : IA IB ou sels pharmaceutiquement acceptables de ceux-ci qui possèdent une activité inhibitrice de la CSF-1R kinase et sont, en conséquence, utiles pour leur activité anti-cancer et de ce fait dans des méthodes de traitement du corps humain ou animal. L'invention porte également sur des procédés de fabrication desdits composés chimiques, sur des compositions pharmaceutiques les contenant et sur leur utilisation dans la fabrication de médicaments destinés à être utilisés dans la production d'un effet anti-cancer dans un animal à sang chaud tel que l'homme.

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