4-(aroylamino)piperidinebutanamide derivatives

Details 4-(aroylamino)piperidinebutanamide derivatives 4-(aroylamino)piperidinebutanamide derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/278

C07D 211/58 (2006.01) A61K 31/445 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1311755

ABSTRACT 4-(AROYLAMINO)PIPERIDINEBUTANAMIDE DERIVATIVES A method of treating warm-blooded animals suffering from diarrhea, which method comprises the administration of particular 4-(aroylamino)piperidinebutanamide derivatives and compositions containing the same. The novel 4- (aroylamino)piperidinebutanamide derivatives have the general formula Image (I) . wherein R1 is a member selected from the group consisting of hydrogen,C1-6alkyl, arylC1-6alkyl, C1-6alkylcarbonyl, aminoC1-6alkyl and mono- and di(C1-6alkyl)aminoC1-6alkyl; R2 is a member selected from the group consisting of hydrogen and C1-6alkyl; Ar is thienyl, halothienyl, furanyl, halofuranyl, pyridinyl, amino- pyridinyl, thiazolyl, imidazolyl or a radical of formula Image (a-1) wherein R3, R4 and R5 are each independently selected from the group consisting of hydrogen, C1-6alkyl, C1-6alkyloxy. halo, hydroxy, cyano, nitro, amino, mono- and di(C1-6alkyl)amino, amino- carbonyl, arylcarbonylamino, C1-6alkylcarbonylamino. C1-6alkyl- carbonyl, C1-6alkylcarbonyloxy. aminosulfonyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkylthio, mercapto, C3-6alkynyloxy, C3-6alkenyloxy, arylC1-6alkyloxy, aryloxy and C1-6alkyl substituted with up to 4 halo atoms; Alk is -CH2-CH2- or -CH2-CH(CH3)-; Ar1 and Ar2 are, each independently, phenyl or halophenyl; R6 and R7 are, each independently, hydrogen, Cl-6alkyl, phenylmethyl or 2-propenyl or R6 and R7 combined with the nitrogen atom bearing said R6 and R7 may form a pyrrolidinyl, piperidinyl, Cl-6alkylpiperidinyl, 4-morpholinyl or 2,6-di(C1-6alkyl)-4- morpholinyl radical; wherein aryl is a member selected from the group consisting of phenyl being optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, hydroxy, Cl-6alkyl, Cl-6alkyloxy, aminosulfonyl, Cl-6alkylcarbonyl, nitro, trifluoromethyl, amino. aminocarbonyl and phenylcarbonyl, said phenylcarbonyl being optionally substituted with up to 3 halo atoms; and thienyl being optionally substituted with halo or Cl-6alkyl.

539401

Affiliated with

Also associated with

Rating

4-(aroylamino)piperidinebutanamide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-(aroylamino)piperidinebutanamide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-(aroylamino)piperidinebutanamide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1293450