4-aroylimidazol-2-ones

Details 4-aroylimidazol-2-ones 4-aroylimidazol-2-ones

C - Chemistry, Metallurgy

07

D

260/314.7

C07D 233/70 (2006.01)

Patent

CA 1173047

NOVEL 4-AROYLIMIDAZOL-2-ONES ABSTRACT OF THE DISCLOSURE Novel 4-aroylimidazol-2-ones of the following general structure which are useful as antihypertensives, cardio- tonics and antithrombotics Image wherein Ar is 2-furyl, 2-thienyl or phenyl, the latter of which may optionally be substituted with one or two X groups; X is halogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, methylenedioxy, C1-4 alkylthio, C1-4 alkylsulfoxide, C1-4 alkylsulfone, CF3, -SO2N(R2)2, NR3R4, pyrrolidino, piperi- dino, morpholino, piperazino or N'-alkyl-piperazino, R is hydrogen, C1-4 alkyl, C1-4 alkylcarbonyl or benzyl; each of R1, R2, R3 and R4 are hydrogen or C1-4 alkyl; and the pharmaceutically acceptable salts thereof.

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