4-aryl-2-amino-pyrimidines or...

Details 4-aryl-2-amino-pyrimidines or... 4-aryl-2-amino-pyrimidines or...

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 453/02 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2640398

This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

La présente invention concerne certains inhibiteurs de la JAK-2, dérivés de la pyrimidine, de la formule (I) : D, E, L, Z, R1, R2, R25 et n1 étant tels que définis dans la description, des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques de ceux-ci et leurs procédés d'utilisation.

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