4-(aryl or heteroaryl)-2-butylamine derivatives and their...

Details 4-(aryl or heteroaryl)-2-butylamine derivatives and their... 4-(aryl or heteroaryl)-2-butylamine derivatives and their...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4045 (2006.01) A61K 31/407 (2006.01) A61K 31/4184 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/443 (2006.01) A61K 31/4439 (2006.01) A61K 31/47 (2006.01) C07D 209/14 (2006.01) C07D 213/38 (2006.01) C07D 213/61 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 215/18 (2006.01) C07D 235/14 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2486491

A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

L'invention concerne un composé de la formule (IA) ou de la formule (IB) dans lesquelles R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ ont la notation définie dans la description, ou un tautomère, un promédicament, un solvate ou un sel de celui-ci; des compositions pharmaceutiques contenant ces composés ainsi que des procédés de modulation de la fonction de récepteur de glucocorticoïde et des méthodes de traitement d'états ou de conditions pathologiques induites par la fonction récepteur de glucocorticoïde ou bien caractérisés par des processus inflammatoires, allergiques ou prolifératifs chez un patient à l'aide de ces composés.

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