C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/44 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07D 401/04 (2006.01) C07D 409/04 (2006.01)
Patent
CA 2159071
The 4-arylisoindoles of formula (I) are effective analgesics including stereoisomers and pharmaceutically acceptable salts thereof, wherein (II) is (III), (IV) or (V); with the proviso that there is 0 or 1 unsaturated bond in the isoindole ring and with the proviso that where the stereoisomer is: a) the 3a.beta., 4.beta., 7a.alpha. diastereomer, then a double bond joints the 5- and 6-position carbons or the 6- and 7-position carbons; b) the 3a.beta., 4.alpha., 7a.alpha. or the 3a.beta., 4.alpha., 7a.beta. diastereomers, then the double bond joins the 5- and 6-position carbons; and c) the 3a.beta., 4.beta., 7a.beta. diastereomer, then the double bond joins the 6- and 7- position carbons.
Carmosin Richard J.
Carson John R.
Liotta Dennis C.
Pitis Philip
Raffa Robert B.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho Pharmaceutical Corporation
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