4-aryloxindoles as inhibitors of jnk protein kinases

Details 4-aryloxindoles as inhibitors of jnk protein kinases 4-aryloxindoles as inhibitors of jnk protein kinases

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/40 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2354591

Novel 4-aryloxindoles having formula (I), where, R2, R3, X and A as set forth in the specification inhibit or modulate protein kinases, in particular JNK protein kinases and are useful as anti-inflammatory agents, partiuclarly in the treatment of rheumatoid arthritis.

La présente invention concerne de nouveaux 4-aryloxindoles représentés par la formule (I), dans laquelle R?2¿, R?3¿, X et A tels que décrits dans le descriptif inhibent ou modulent les protéines kinases, en particulier les protéines kinases JNK. En outre, ils sont utilisés comme anti-inflammatoires, particulièrement dans le traitement de l'arthrite rhumatoïde.

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