4-aryloxy-1,2,3,4-tetrahydroisoquinolines, and...

Details 4-aryloxy-1,2,3,4-tetrahydroisoquinolines, and... 4-aryloxy-1,2,3,4-tetrahydroisoquinolines, and...

C - Chemistry, Metallurgy

07

D

260/277.1, 260/2

C07D 217/24 (2006.01) C07D 401/06 (2006.01)

Patent

CA 1173833

Abstract of the Disclosure: This invention relates to 4-aryioxy-1,2,3,4-tetra- Hydroisoquinolines or the formula Image where Y is hydrogen and alkoxy; X is hydrogen, cyano, benzoyl, trifluoromethyl, phenyl, halogen, alkyl, alkoxy and nitro; R is hydrogen and alkyl; R1 is hydrogen, alkyl, aralkyl, Image and CO2R4, where R4 is aryl and alkyl; R2 and R3 are the same or different and are hydrogen and alkyl or R2 and are fused together to form a pyrrolidino or a piperidino ring substituent; and m 13 an integer Or 1 or 2; n is an integer or 2 or 3; and a pharmaceuticall acceptable acid addition salt thereof.

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