C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/08 (2006.01) A61K 31/433 (2006.01) A61K 31/437 (2006.01) A61K 31/4427 (2006.01) A61P 3/10 (2006.01) A61P 29/00 (2006.01) C07D 403/08 (2006.01) C07D 413/08 (2006.01) C07D 417/08 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2758918
The present invention comprises compounds of Formula (I). Formula (I). wherein: X, R1, R2, R3, and R4 are as de-fined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of For-mula (I).
La présente invention concerne des composés de formule (I). Formule (I). Dans cette formule, X, R1, R2, R3 et R4 sont tels que définis dans la description. L'invention concerne également une méthode de prévention, de traitement ou d'amélioration d'un syndrome, d'un trouble ou d'une maladie, ledit syndrome, trouble ou maladie étant le diabète de type II, l'obésité et l'asthme. L'invention concerne également une méthode d'inhibition de l'activité de CCR2 chez un mammifère par administration d'une quantité thérapeutiquement efficace d'au moins un composé de formule (I).
Cai Chaozhong
Hufnagel Heather Rae
Lanter James
Markotan Thomas P.
Sui Zhihua
Janssen Pharmaceutica Nv
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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