C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/41 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/4196 (2006.01) A61K 31/422 (2006.01) A61P 3/08 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2539726
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders. Formula (I) where Q is C1-6 alkylidene chain wherein one methylene unit of Q is replaced by -C(O)N(R)-, -C(O)-, -C(O)O-, - N(R)-, -O-, -S-, -SO2-, or -SO2N(R)-; each R is independently hydrogen or an optionally substituted C1-6 aliphatic group, wherein: two R groups on the same nitrogen atom are optionally taken together with said nitrogen atom to form an optionally substituted 3-7 membered saturated, partially unsaturated, of fully unsaturated ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R1 is H, -N(R)2, or an optionally substituted ring selected from a 3-7 membered saturated or partially unsaturated ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 5-6 membered aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an 8-10 membered bicyclic partially unsaturated or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R2 is an optionally substituted 6-membered aryl ring having 0-3 nitrogens; R3 is R, CN, NO2, halogen, N(R)2, OR, or SR; and Ring A is an optionally substituted ring selected from formulas (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o) or (p).
La présente invention concerne des composés utilisés comme inhibiteurs des protéines kinases. L'invention porte aussi sur des procédés de préparation des composés précités, sur des compositions pharmaceutiquement acceptables renfermant les composés de l'invention, et sur des procédés d'utilisation desdites compositions dans le traitement de diverses affections.
Aronov Alexander
Lauffer David
Li Pan
Tomlinson Ronald
Smart & Biggar
Vertex Pharmaceuticals Incorporated
LandOfFree
4-azole substituted imidazole compositions useful as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4-azole substituted imidazole compositions useful as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-azole substituted imidazole compositions useful as... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1825077