4-benzyl-1-[2-(4-hydroxy-phenoxy)-ethyl]-piperidine-3,4-diol

Details 4-benzyl-1-[2-(4-hydroxy-phenoxy)-ethyl]-piperidine-3,4-diol 4-benzyl-1-[2-(4-hydroxy-phenoxy)-ethyl]-piperidine-3,4-diol

C - Chemistry, Metallurgy

07

D

C07D 211/50 (2006.01) A61K 31/44 (2006.01) A61P 25/28 (2006.01) C07D 211/48 (2006.01)

Patent

CA 2407345

The invention relates to a compound of formula (I), its R,R- and S,S-enantiomeres and to their pharmaceutically acceptable acid addition salts. The compound of formula (I) and its R,R-- and S,S-enantiomeres may be used as medicaments for the treatment of diseases, wherein the therapeutic indications include acute forms of neurodegeneration caused by stroke or brain trauma; chronic forms of neurodegeneration such as Alzheimer's disease, Parkinson's disease, Huntington's disease or ALS (amyotrophic lateral sclerosis); neurodegeneration associated with bacterial or viral infections, and diseases such as schizophrenia, anxiety, depression and chronic/acute pain.

L'invention concerne un composé de formule (I), ses énantiomères R,R et S,S et leurs sels d'addition acide pharmaceutiquement acceptables. Le composé de formule (I) et ses énantiomères R,R et S,S peuvent être utilisés comme médicaments pour le traitement de maladies, les indications thérapeutiques incluant des formes aiguës de neurodégénérescence provoquées par un accident vasculaire cérébral ou un traumatisme du cerveau, des formes chroniques de neurodégénérescence telles que la maladie d'Alzheimer, la maladie de Parkinson, la chorée de Huntington ou la sclérose latérale amyotrophique, une neurodégénérescence associée à des infections bactériennes ou virales et des maladies telles que la schizophrénie, l'anxiété, la dépression et la douleur chronique ou aiguë.

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