C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/314
C07D 233/56 (2006.01) C07C 41/50 (2006.01) C07C 43/313 (2006.01) C07C 43/315 (2006.01) C07C 45/51 (2006.01) C07C 49/245 (2006.01) C07C 49/258 (2006.01) C07D 233/54 (2006.01) C07D 263/32 (2006.01)
Patent
CA 1154780
ABSTRACT OF THE DISCLOSURE Compounds of the formula: Image (I) wherein R1, R2 and R3, which can be the same or different, are each selected from the group consisting of hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy and nitro; R4 is selected from the group consisting of hydrogen and an alkyl group containing 1 to 7 car- bon atoms; -X- is selected from the group consisting of Image and Image ; R5 is selected from the group consisting if hydrogen, hydroxy and -OR6-; and R6 is selected from the group consisting of an alkyl group containing 1 to 7 carbon atoms and an aryl group containing 6 to 10 carbon atoms; and their non-toxic pharmaceutically acceptable acid addition salts and mixtures thereof with the proviso that when -R1, R2 and R3 are simultaneously hydrogen and R4 is hydrogen or methyl, then -Y- cannot be Image or Image -R1, R2, R3 are simultaneously hydrogen and R4 is hydrogen, methyl or ethyl, then -Y- cannot be -CH2- -R1 is 2-methyl, R2 is 5-methyl, R3 is hydrogen and R4 is methyl, then -Y- cannot be -CH2- are provided herein. Processes for the preparation of the above-identi- fied compounds are also described. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are useful in the treatment of mammals, particularly as anti-hypertensive or anti-ulcer agents. Furthermore, they are useful as diuretic, sedative, analgesic, anti-inflammatory and tranquilizing agents.
357663
Karjalainen Arto J.
Kurkela Kauko O.a.
Borden Ladner Gervais Llp
Farmos - Yhtyma Oy
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