4-(benzylideneamino)-3-(methylsulfanyl)-4h-1,2,4-triazin-5-o...

Details 4-(benzylideneamino)-3-(methylsulfanyl)-4h-1,2,4-triazin-5-o... 4-(benzylideneamino)-3-(methylsulfanyl)-4h-1,2,4-triazin-5-o...

C - Chemistry, Metallurgy

07

D

C07D 253/07 (2006.01) A61K 31/53 (2006.01) C07D 253/075 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2453974

The invention relates to triazine derivatives of formula (I), and the physiologically compatible salts and solvates thereof, wherein R1, R2, A and R5 have the designations cited in claim 1. Said derivatives exhibit a phosphodiesterase IV-inhibiting action and can be used for the treatment of allergic diseases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, auto-immune diseases such as rheumatoid arthritis, multiple sclerosis, Crohn's disease, pancreatic diabetes or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumour growth or tumour metastases, sepsis, memory defects, arteriosclerosis and AIDS. Said derivatives can also be used to inhibit the formation of TNF .alpha..

Dérivés de triazine de formule (I), ainsi que leurs sels et solvats physiologiquement compatibles, dans laquelle R?1¿, R?2¿, A et R?5¿ possède la signification figurant à la revendication 1. Lesdits dérivés possèdent une action d'inhibition de la phosphodiestérase IV et peuvent être utilisés pour traiter les maladies allergiques, l'asthme, la bronchite chronique, la dermatite atopique, le psoriasis et d'autres maladies de la peau, les maladies inflammatoires, les maladies auto-immunes telles que par ex. la polyarthrite rhumatoïde, la sclérose en plaques, la maladie de Crohn, le diabète sucré, la recto-colite hémorragique, l'ostéoporose, les réactions de rejet lors de transplantations, la cachexie, la croissance tumorale ou les métastases, la sepsie, les troubles de la mémoire, l'athérosclérose et le sida, ainsi que pour inhiber la formation de TNF.alpha..

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