4-benzylpiperidine derivatives and process for their production

Details 4-benzylpiperidine derivatives and process for their production 4-benzylpiperidine derivatives and process for their production

C - Chemistry, Metallurgy

07

D

C07D 211/08 (2006.01) A61K 31/445 (2006.01) C07D 211/14 (2006.01) C07D 211/18 (2006.01) C07D 221/20 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2096611

4-Benzylpiperidine derivatives of the formula Image (I) or a pharmaceutically acceptable acid addition salts thereof, wherein X is hydrogen or fluorine and R is hydrogen, or a group selected from p-fluorobenzoyl, alpha-hydroxy-p-fluorobenzyl, p-fluorophenoxy, bis(p-fluoro-phenyl)methyl and 8-azaspiro [4,7] decane-7,9-dione-8-yl-methyl with the proviso that X and R may not be simultaneously hydrogen and p-fluorobenzoyl respectively. Such compounds are useful as sigma-receptor ligands.

Dérivés de la 4-benzylpipéridine de formule Image (I) ou sels d'addition acide pharmaceutiquement acceptables de ces derniers, où X est un atome d'hydrogène ou de fluor et R est un hydrogène ou un groupe choisi parmi le p-fluorobenzoyle, l'alpha-hydroxy-p-fluorobenzyle, le p-fluorophénoxy, le bis(p-fluoro-phényl)méthyle et le 8-azaspiro [4,7]décane-7,9-dione-8-yl-méthyle à la condition que X et R ne puissent être simultanément un atome d'hydrogène et du p-fluorobenzoyle, respectivement. Ces composés sont utiles comme ligands du récepteur sigma.

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