C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/12 (2006.01) A61K 31/165 (2006.01) C07C 259/10 (2006.01) C07D 211/22 (2006.01) C07D 295/08 (2006.01) C07D 295/088 (2006.01) C07D 307/42 (2006.01) C07D 309/06 (2006.01) C07D 333/16 (2006.01)
Patent
CA 2290506
Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
On décrit des dérivés d'acide benzhydroxamique phénylamino de formule (I). Dans la formule R1, R2, R3, R4, R5 et R6 représentent hydrogène ou des groupes substituants tels que alkyle; R7 représentant hydrogène ou un radical organique. Ces dérivés sont de puissants inhibiteurs de MEK et en tant que tels ils sont efficaces dans le traitement du cancer et d'autres maladies proliférantes telles que le psoriasis et la resténose.
Barrett Stephen Douglas
Bridges Alexander James
Doherty Annette Marian
Dudley David Thomas
Saltiel Alan Robert
Macrae & Co.
Warner-Lambert Company
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