4'-c-ethynyl pyrimidine nucleoside compounds

Details 4'-c-ethynyl pyrimidine nucleoside compounds 4'-c-ethynyl pyrimidine nucleoside compounds

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) A61K 31/7064 (2006.01)

Patent

CA 2308192

The invention provides 4'-C-ethynyl pyrimidine nucleosides (other than 4'-C-ethynylthymidine) represented by formula [I]: (see formula I) wherein B represents a base selected from the group consisting of pyrimidine and derivatives thereof; X represents a hydrogen atom or a hydroxyl group; and R represents a hydrogen atom or a phosphate residue; and a pharmaceutical composition containing any one of the compounds and a pharmaceutically acceptable carrier. Preferably, the composition is used as an anti-HIV agent or a drug for treating AIDS.

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