4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines

Details 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines

C - Chemistry, Metallurgy

07

D

C07D 215/42 (2006.01) A61K 31/4706 (2006.01)

Patent

CA 2344556

Cholesteryl ester transfer protein inhibitors of formula (I), pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein- cholesterol and to lower certain other plasma lipid levels, such as LDL- cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL- cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

Cette invention, qui a trait à des inhibiteurs de la protéine de transfert d'ester de cholestéryle correspondant à la formule (I), porte également sur des compositions pharmaceutiques les contenant ainsi que sur l'utilisation qui est faite de ces inhibiteurs pour élever certains taux de lipide plasmatique, notamment le taux de lipoprotéine-cholestérol de haute densité, ainsi que pour abaisser d'autres taux de lipide plasmatique, notamment le taux de lipoprotéine-cholestérol de basse densité et le taux de triglycérides et, partant, pour traiter des troubles exacerbés par de faibles taux de lipoprotéine-cholestérol de haute densité et/ou par des taux élevés de lipoprotéine-cholestérol de basse densité et de triglycérides, comme l'athérosclérose et certaines maladies cardio-vasculaires propres à certains mammifères, humains compris.

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