4-chloro-3-sulfamoylbenzoic acid hydrazides, a process for...

Details 4-chloro-3-sulfamoylbenzoic acid hydrazides, a process for... 4-chloro-3-sulfamoylbenzoic acid hydrazides, a process for...

C - Chemistry, Metallurgy

07

D

167/237, 260/314

C07D 235/04 (2006.01) A61K 31/415 (2006.01) C07D 235/22 (2006.01) C07D 235/26 (2006.01) C07D 235/28 (2006.01)

Patent

CA 1332739

ABSTRACT OF THE DISCLOSURE The present invention relates to novel compounds of the general formula (I) Image wherein R is a hydrogen atom or a trifluoromethyl, carboxy, C2-5- alkoxycarbonyl, cyano, benzoyl, sulfamoyl or C1-4 alkylsulfonyl group; R1 is a hydrogen atom or a linear or branched chain C1-4- alkyl, C1-4 alkylthio, C1-4 alkysulfonyl, benzylthio, benzyl- sulfonyl, phenyl, hydroxy or a mercapto group, and R2 is a hydrogen or chlorine atom, as well as their pharmaceutically acceptable salts. The compounds according to the invention possess diuretic and saluretic activity with an advantageous Na/k ratio.

587184

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