4-cyanophenylamino-substituted bicyclic heterocyclic...

Details 4-cyanophenylamino-substituted bicyclic heterocyclic... 4-cyanophenylamino-substituted bicyclic heterocyclic...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2668997

This application concerns certain 4-cyanophenylamino-substituted bicyclic heterocycles of formula (I) where the dashed line represents a double bond that may be located either between A and C(V) or between C(V) and D, where A is S or C(Z); D is S or C(W); provided that one and only one of A and D is S; where T is NH, O, or S; and where other substituents are defined herein. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.

La présente invention concerne certains hétérocycles bicycliques 4-cyanophénylamino-substitués représentés par la formule (I) dans laquelle: la ligne en pointillés représente une liaison double qui peut se trouver soit entre A et C(V), soit entre C(V) et D; A représente S ou C(Z); D représente S ou C(W), à condition que soit A, soit D désigne S; T représente NH, O ou S; d'autres substituants étant définis dans la description. Ces composés sont des inhibiteurs non nucléosidiques de la transcriptase inverse et peuvent être utilisés comme traitement contre le VIH.

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