4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists

Details 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2535347

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological conditions such as, for example, pain, Parkinson~s disease, Alzheimer~s disease, epilepsy, depression, anxiety, ischemic brain injury including stroke, and other conditions.

La présente invention concerne des composés représentés par la formule (I), ou certains de leurs sels pharmaceutiquement admis. Ces produits, qui se comportent comme des antagonistes des NMDA/NR2B, conviennent particulièrement au traitement d'états neurologiques tels que la douleur, les maladies de Parkinson et d'Alzheimer, l'épilepsie, la dépression, l'anxiété, les lésions ischémiques cérébrales, y compris les attaques, et d'autres états.

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