4-desoxy-thiazolo-¬5,4-c|rifamycin derivatives, a process...

Details 4-desoxy-thiazolo-¬5,4-c|rifamycin derivatives, a process... 4-desoxy-thiazolo-¬5,4-c|rifamycin derivatives, a process...

C - Chemistry, Metallurgy

07

D

260/235.82

C07D 513/18 (2006.01) C07D 498/08 (2006.01)

Patent

CA 1104131

ABSTRACT OF THE DISCLOSURE Novel 4-desoxy-thiazolo[5,4-c]rifamycin derivatives of formula I Image (I) wherein R stands for a group -OR1, -NR2R3 or -NHCOR4, wherein R1 represents alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl, R2 and R3 are inde- pendently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl and aralkyl or R2 and R3 taken together with the adjacent nitrogen atom represent a 5- to 7- membered heterocyclic ring, and R4 represents alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl; and R5 is hydrogen or acetyl are disclosed, together with a process for preparing them. The novel com- pounds have an antibacterial utility.

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