4-diphenylmethane-4-diphenylmethylene and...

Details 4-diphenylmethane-4-diphenylmethylene and... 4-diphenylmethane-4-diphenylmethylene and...

C - Chemistry, Metallurgy

07

D

260/278.1, 260/2

C07D 211/08 (2006.01)

Patent

CA 1067902

Abstract of The Disclosure Compounds of the following general formula are useful as antihistamine agents antiallergy agnets and broncho- dilators: Image wherein R represents hydrogen or hydroxy; R1 represents hydrogen; or R and R1 taken together form a second bond between the carbon atoms bearing R and R1; n is the integer 4 or 5; Y represents -?-, Image or Image ; Z represents phenyl or a substituted phenyl eing wherein the substituent on the substituted phenyl ring is attached at the ortho, meta, or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, alkoxy of from 1 to 6 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group selected from pyrrolidino, piperidino, morpholino or N-(lower)alkyl- piperazino; and pharmaceutically acceptable acid addition salts and individual optical isomers.

313625

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