4-diphenylmethane-4-diphenylmethylene-and...

Details 4-diphenylmethane-4-diphenylmethylene-and... 4-diphenylmethane-4-diphenylmethylene-and...

C - Chemistry, Metallurgy

07

D

260/278, 260/292

C07D 401/06 (2006.01) C07D 211/08 (2006.01) C07D 211/14 (2006.01) C07D 211/22 (2006.01) C07D 211/70 (2006.01) C07D 295/18 (2006.01)

Patent

CA 1053678

PIPERIDINE DERIVATIVES Abstract of The Disclosure Compounds of the following general formula are useful as antihistamine agents, antiallergy agents and broncho- dilators: Image wherein R represents hydrogen or hydroxy; R1 represents hydrogen; or R and R1 taken together form a second bond between the carbon atoms bearing R and R1; n is the integer 4 or 5; Y represents -?-, -?- or -?H- ; Z represents phenyl or a substituted phenyl ring wherein the substituent on the substituted phenyl ring is attached at the ortho, meta, or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, alkoxy of from 1 to 6 carbon atoms, cycloalkyl of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group selected from pyrrolidino, piperidino, morpholino or N-(lower)alkyl- piperazino; and pharmaceutically acceptable acid addition salts and individual optical isomers.

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