4-fluoro-n-indan-2-yl benzamide and its use as pharmaceutical

A - Human Necessities – 61 – K

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A61K 31/166 (2006.01) A61P 9/00 (2006.01) C07C 233/65 (2006.01)

Patent

CA 2437966

The present invention relates to 4-fluoro-N-indan-2-yl benzamide according to the formula (I), and its use as pharmaceutical. The compound (1) can be used for the therapy and prophylaxis of cardiovascular diseases like stable and unstable angina pectoris, Prinzmetal angina (spasm), acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease PAOD, atherosolerosis, restenosis, endothel damage after PTCA, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, and the lowering of cardiovascular risk of Postmenopausal women or aft intake of contraceptives, the therapy and

La présente invention concerne du 4-fluoro-N-indan-2-yle benzamide de formule (I) et son utilisation comme agent pharmaceutique. Le composé (I) peut être utilisé pour traiter et prévenir des maladies cardiovasculaires telles que l'angine de poitrine stable et instable, l'angor de Prinzmetal (spasme), le syndrome coronarien aigu, l'insuffisance cardiaque, l'infarctus du myocarde, l'accident vasculaire cérébral, la thrombose, la maladie occlusive artérielle périphérique (PAOD), l'athérosclérose, la resténose, les lésions endothéliales après ACTP, l'hypertension essentielle, l'hypertension pulmonaire, l'hypertension secondaire, la glomérulonéphrite chronique rénovasculaire, la dysérection et l'arythmie ventriculaire. Ledit composé peut également être utilisé pour diminuer les risques cardiovasculaires associés aux femmes postménopausiques ou liés à l'ingestion de contraceptifs, et pour traiter et prévenir le diabète et les complications du diabète (néphropathie, rétinopathie), l'angiogenèse, l'asthme bronchique, l'insuffisance rénale chronique, la cirrhose du foie ainsi que la perte des facultés de mémoire ou d'apprentissage.

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