4-fluoroalkyl-substituted benzoylguanidines, process for...

Details 4-fluoroalkyl-substituted benzoylguanidines, process for... 4-fluoroalkyl-substituted benzoylguanidines, process for...

C - Chemistry, Metallurgy

07

C

C07C 317/32 (2006.01) A61K 31/16 (2006.01) A61K 31/395 (2006.01) A61K 49/00 (2006.01) C07C 279/22 (2006.01) C07C 311/46 (2006.01) C07C 317/44 (2006.01) C07C 323/42 (2006.01) C07D 207/36 (2006.01) C07D 213/62 (2006.01) C07D 215/16 (2006.01) C07D 217/22 (2006.01) C07D 233/66 (2006.01) C07D 295/26 (2006.01)

Patent

CA 2181515

4-Fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them There are described benzoylguanidines of the formula I Image I where R(1) is R(4)-SOm, R(5)R(6)N-SO2-; -Op-(CH2)q-(CF2)r-CF3; -SR(10), -OR(10) or -CR(10)R(11)R(12); R(2) is -(CH2)u-(CF2)t-CF3; R(3) is hydrogen or independently defined as R(1); and their pharmaceutically tolerable salts. They are obtained by reaction of a compound of the formula II Image II with guanidine. They are compounds of outstanding activity on the cardiovascular system.

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