4-formylamino and 4-acetylamino vlb

Details 4-formylamino and 4-acetylamino vlb 4-formylamino and 4-acetylamino vlb

C - Chemistry, Metallurgy

07

D

260/237.3

C07D 519/04 (2006.01)

Patent

CA 1160630

x-4771-(A) Abstract Dimeric indole-dihydroindole compounds of the formula I Image wherein R is OCH3, NH2, NHCH3, NHC2H5, NHC2H4OH or NH-NH2; R1 is OH or acetoxy; R2 is CH3 or CHO; and R4 is NH-C-R wherein R is H, methyl, NHCOO methy] or methylthliomethyl; and their Pharmaceutically-acceptable acid addition salts, active as anti-tumor agents in mammals, are prepared from their C-4' hydroxy analogues by reaction with hydrogen cyanide or nitriles under strongly acidic conditions.

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