C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/40 (2006.01) C07D 207/00 (2006.01) C07D 209/00 (2006.01) C07D 213/00 (2006.01) C07D 233/00 (2006.01) C07D 401/04 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2414468
The present invention relates to certain 4-heteroaryl-3-heteroarylidenyl-2- idolinones compounds and their physiologically acceptable salts which modulate the activity of protein kinases ("PKs"), in particular CDK2. The compounds of the present invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical composition containing these compounds and methods of preparing these compounds are also described.
La présente invention concerne certains composés 4-hétéroaryl-3-hétéroarylidényl-2-idolinones et certains de leurs sels qui, physiologiquement acceptables, modulent l'activité des protéine kinases (PK), en particulier la CDK2. Il en résulte que les composés de l'invention conviennent pour le traitement de troubles liés à une activité PK anormale. L'invention concerne également, d'une part une composition pharmaceutique à base de ces composés, et d'autre part des procédés pour leur élaboration.
Cui Jingrong
Huang Ping
Tang Peng Cho
Wei Chung Chen
Osler Hoskin & Harcourt Llp
Sugen Inc.
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