4-heterocyclophenyl-substituted dihydropyridines

Details 4-heterocyclophenyl-substituted dihydropyridines 4-heterocyclophenyl-substituted dihydropyridines

C - Chemistry, Metallurgy

07

D

C07D 413/10 (2006.01) A61K 31/44 (2006.01) C07D 211/90 (2006.01) C07D 401/10 (2006.01) C07D 405/10 (2006.01)

Patent

CA 2109342

4-Heterocyclophenyl-substituted dihydropyridines A b s t r a c t 4-Heterocyclophenyl-substituted dihydropyridines are prepared either by reacting suitable aldehydes with amino esters and .beta.-keto esters, or preparing the heterocyclic substituents of the 4-phenyl by cyclization of corresponding amidines or hydrazides, or esterifying dihydropyridinecarboxylic acids, which are already substituted by heterocyclic radicals, with corresponding alcohols. The 4-heterocyclophenyl-substituted dihydropyridines can be employed in medicaments, in particular for treatment of diseases of the central nervous system.

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