4-(heterocyclylsulfonamido)-5-methoxy-6-(2-methoxyphenoxy)-2...

Details 4-(heterocyclylsulfonamido)-5-methoxy-6-(2-methoxyphenoxy)-2... 4-(heterocyclylsulfonamido)-5-methoxy-6-(2-methoxyphenoxy)-2...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2359363

The compounds of formula (I) wherein R1, R2 and X have the significance as given in the description, are inhibitors of endothelin receptors and can therefore be used for the treatment of disorders which are associated with abnormal vascular tone and endothelial dysfunction.

L'invention concerne des composés de formule (I), dans laquelle R<1>, R<2> et X ont la même signification que dans la description. Ces composés sont des inhibiteurs des récepteurs de l'endothéline et peuvent donc être utilisés pour traiter les troubles liés à un tonus vasculaire anormal et à un dysfonctionnement endothélial.

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