4-hydroxy-1,2-benzisothiazole and their manufacture

Details 4-hydroxy-1,2-benzisothiazole and their manufacture 4-hydroxy-1,2-benzisothiazole and their manufacture

C - Chemistry, Metallurgy

07

D

260/309.1

C07D 275/04 (2006.01)

Patent

CA 1105032

ABSTRACT OF THE DISCLOSURE: The present invention relates to 1,2-benzisothiazoles of the general formula (I) : Image (I) where R1 is hydrogen, amino, which is unsubstituted or sub- stituted by the acyl radical of an organic acid of 1 to 4 carbon atoms, or nitro, and where the phenolic hydroxyl may or may not be etherified by benzyl or esterified by the radical of an organic acid of 1 to 4 carbon atoms. The invention more particularly relates to 4-hydroxy-1,2-benzisothiazole and its derivatives, and their process of preparation. These products are intermediates for new drugs which are useful in cardiac and circulatory disorders.

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