4-hydroxy-4-methyl-piperidine-1-carboxylic acid...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 417/12 (2006.01) A61K 31/454 (2006.01) A61P 25/28 (2006.01) A61P 25/36 (2006.01)

Patent

CA 2567703

The present invention relates to the compound of formula (I): which is 4- hydroxy-4-methyl-piperidine-l-carboxylic acid (4-methoxy-7-morpholin-4~-yl- benzothiazol-2-yl)-amide, and pharmaceutically acceptable acid addition salts thereof. It has been found that the compound is useful for the treatment or prevention of Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, ADHD ( attention deficit hyper-activity disorder), drug addiction to amphetamines, cocaine, opioids, ethanol, nicotine, cannabinoids, or for the treatment of asthma, allergic responses, hypoxia, ischemia, seizure, substance abuse, or for use as muscle relaxants, antipsychotics, antiepileptics, anticonvulsants and cardioprotective agents.

La présente invention concerne le composé représenté par la formule (I), qui est de l'acide 4-hydroxy-4-méthyl-pipéridine-1-carboxylique (4-méthoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide, ainsi que des sels d'addition acides pharmaceutiquement acceptables de ce dernier. On a découvert que le composé est utile pour le traitement ou la prévention de la maladie d'Alzheimer, de la maladie de Parkinson, de la maladie de Huntington, de la neuroprotection, de la schizophrénie, de l'anxiété, de la douleur, des insuffisances respiratoires, de la dépression, du TDAH (trouble déficitaire de l'attention avec hyperactivité), de la pharmacodépendance aux amphétamines, à la cocaïne, aux opioïdes, à l'éthanol, à la nicotine, aux cannabinoïdes, ou pour le traitement de l'asthme, des réponses allergiques, de l'hypoxie, de l'ischémie, de la crise épileptique, de la toxicomanie, ou pour être utilisée en tant que myorelaxants, qu'antipsychotiques, qu'antiépileptiques, qu'anticonvulsivants et qu'agents cardioprotecteurs.

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