4-hydroxy-piperidine derivatives

Details 4-hydroxy-piperidine derivatives 4-hydroxy-piperidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) C07D 211/44 (2006.01) C07D 211/48 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2220649

The present invention relates to 4-hydroxy-piperidine derivatives of the general formula (see formula I) wherein X denotes -O-, -NH-, -CH2-, -CH=, -CHOH-, -CO-, -S-, -SO- or -SO2-; R1-R4 are, independently from each other, hydrogen, hydroxy, lower alkyl-sulfonylamino, 1- or 2-imidazolyl or acetamido; R5-R8 are, independently from each other, hydrogen, hydroxy, lower- alkyl, halogen, lower-alkoxy, trifluoromethyl or trifluoro- methyloxy; a and b may be a double bond, provided that when "a" is a double bond, "b" cannot be a double bond; n is 0-2; m is 1-3; p is 0 or 1 and to pharmaceutically acceptable addition salts thereof. Compounds of the present invention are NMDA(N-methyl-D-aspartate)- receptor subtype selective blockers, which can be used in mediating processes underlying development of CNS including learning and memory formation and function.

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