4-hydroxyphenylalkanolamine derivatives and preparation thereof

C - Chemistry – Metallurgy – 07 – C

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260/602.3, 260/4

C07C 217/62 (2006.01)

Patent

CA 1091245

ABSTRACT OF THE DISCLOSURE Alpha-(aminoalkyl)-4-hydroxy-3-(alkylthio, alkylsulfin- yl or alkylsulfonyl)benzenemethanols and 2-[4-hydroxy-3-(alkyl- thio, alkylsulfinyl or alkylsulfonyl)phenyl]ethylamines useful as antihypertensive agents are prepared by reduction of the corre- sponding aminoalkyl 4-hydroxy-3-(alkylthio, alkylsulfinyl or alkyl- sulfonyl)phenyl ketones and 2-chloro, bromo or indo-2-[4-hydroxy- 3-(alkylthio, alkylsulfinyl or alkylsulfonyl)phenyl]ethylamines respectively.

281375

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