4-hydroxypiperidine derivatives having analgesic activity

Details 4-hydroxypiperidine derivatives having analgesic activity 4-hydroxypiperidine derivatives having analgesic activity

C - Chemistry, Metallurgy

07

D

C07D 211/48 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2448509

A compound represented by the following formula (I): (I) [wherein A represents oxygen or a group represented by -NR3- (R3 represents hydrogen or lower alkyl); R1 represents nitro, lower alkoxycarbonyl, carbamoyl optionally substituted by one or two lower alkyls, optionally protected hydroxy, optionally protected carboxyl, lower alkyl substituted by optionally protected hydroxy, or tetrazolyl; and R2 represents hydrogen, cyano, or (lower alkyl)sulfonyl; provided that when A is -NR3- then R1 is neither optionally protected hydroxy nor lower alkyl substituted by optionally protected hydroxy] or a salt thereof; a process for producing the compound; and a medicinal composition containing the compound as the active ingredient.

L'invention concerne un composé représenté par la formule (I) suivante: [dans laquelle A représente oxygène ou un groupe représenté par -NR?3¿- (R?3¿ représente hydrogène ou alkyle inférieur); R?1¿ représente nitro, alcoxycarbonyle inférieur, carbamoyle facultativement substitué par un ou deux alkyles inférieurs, hydroxy optionnellement protégé, carboxyle optionnellement protégé, alkyle inférieur substitué par hydroxy optionnellement protégé, ou tétrazolyle; et R?2¿ représente hydrogène, cyano, ou (alkyle inférieur) sulfonyle; à condition que lorsque A représente -NR?3¿- alors R?1¿ ne représente ni hydroxy optionnellement protégé ni alkyle inférieur substitué par hydroxy optionnellement protégé] ou un sel de celui-ci; un procédé de production du composé et une composition médicinale contenant le composé en tant que principe actif.

Affiliated with

Also associated with

Rating

4-hydroxypiperidine derivatives having analgesic activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-hydroxypiperidine derivatives having analgesic activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-hydroxypiperidine derivatives having analgesic activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2082018