4-imidazolidinones as kv1.5 potassium channel inhibitors

Details 4-imidazolidinones as kv1.5 potassium channel inhibitors 4-imidazolidinones as kv1.5 potassium channel inhibitors

C - Chemistry, Metallurgy

07

D

C07D 235/02 (2006.01) A61K 31/4184 (2006.01) A61P 9/00 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2709187

The present teachings relate to 4-imidazolidinones of Formula (Ia) or (Ib) which are useful as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic activity. The present teachings further relate to compositions and methods for treating atrial-selective antiarrhythmia.

La présente invention concerne des 4-imidazolidinones de formule (Ia) ou (Ib) qui sont utiles comme inhibiteurs du canal potassique KV1.5 fournissant une activité antiarythmique exclusivement atriale. L'invention concerne en outre des compositions et des procédés pour traiter l'antiarythmie exclusivement atriale.

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